Zopiclone (Imovane) is indicated for the short-term remedy and symptomatic relief of insomnia characterised by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.
Treatment with zopiclone ought to normally not exceed 7-10 consecutive days. Use for greater than 2-3 consecutive weeks requires complete re-evaluation of the patient. Prescriptions for zopiclone ought to be written for short-term use (7-10 days) and it should not be prescribed in portions exceeding a 1-month provide.
The use of hypnotics ought to be restricted for insomnia where disturbed sleep leads to impaired daytime functioning.
Dosage and administration:
Imovane should solely be taken when you’ll be able to get a full night’s sleep (7 to 8 hours) earlier than you have to be energetic again.
The normal adult dose of zopiclone is one tablet simply earlier than you go to bed.
This treatment ought to be taken in a single consumption and never readministered during the identical night.
If you would possibly be over 65 years of age the dose is half a pill taken just earlier than you go to mattress.
If you’ve a liver or kidney downside, the standard beneficial dose is half a pill taken just earlier than you go to mattress.
Signs and symptoms:
Overdose by zopiclone tablets is often manifested by varying levels of central nervous system depression ranging from drowsiness to coma based on the amount ingested. In mild instances, signs embrace drowsiness, confusion, and lethargy; in more severe circumstances, symptoms may include ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory depression, and coma. Overdose shouldn’t be life threatening unless mixed with different CNS depressants, including alcohol. Other risk elements, such as the presence of concomitant illness and the debilitated state of the patient, may contribute to the severity of symptoms and really hardly ever can outcome in fatal end result.
In voluntary or accidental instances of zopiclone overdosage involving doses as a lot as 340 mg, the principal results reported have been extended sleep, drowsiness, lethargy and ataxia.
Symptomatic and supportive remedy in adequate clinical surroundings is beneficial, attention must be paid to respiratory and cardiovascular functions. Gastric lavage or activated charcoal is simply useful when carried out quickly after ingestion.
Hemodialysis is of no worth due to the massive quantity of distribution of zopiclone. Flumazenil could additionally be a useful antidote; nevertheless, flumazenil administration could contribute to the looks of neurological symptoms (agitation, anxiousness, convulsionsand emotional lability). Intravenous fluids should be administered as needed.